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Organization Overview
The BioRx group operates at the interface of molecule design and biological function. We advance engineered antibodies, CARs, mRNA-encoded proteins, and nanoparticle delivery systems across autoimmune disease, oncology, neurodegeneration, and pain. Our team is fast and technically deep. Every scientist has direct impact on molecule selection and program decisions. We are building the screening and characterization tech stack that will power rapid design–make–test cycles for new platforms—which means you’ll be building the workflow from the ground up.
We are building an industry-leading in vivo CAR-T platform that delivers mRNA-encoded chimeric antigen receptors to a patient’s T cells directly in the body via targeted nanoparticles—democratizing patient access to cell therapy. Getting this to work requires answering hard biological questions about delivery efficiency, CAR expression kinetics, T cell activation thresholds, and effector function that require new science to answer.
Job Responsibilities
This is a hands-on, lab-based role. You will be the biological engine of our in vivo CAR-T program. Specifically:
Drive molecule SAR
- Own the biological arm of the design–make–test cycle: generate, interpret, and translate screening data into actionable SAR insights that directly inform the next round of molecule design across CARs, mRNA constructs, and TNP/LNP formulations.
- Drive CAR screening activities, including in vitro functional assays, phenotypic characterization, and molecule down-selection to support therapeutic programs.
- Advance pipeline programs by integrating screening data with translational insights to enable clear and timely decision-making.
- Ensure on-time delivery of program objectives and milestones by managing timelines, resources, and cross-functional dependencies.
- Partner with cross-functional groups (e.g., protein engineering, mRNA engineering, formulation, in vivo pharmacology) to ensure alignment on molecule profile and selection criteria.
- Contribute to platform innovation initiatives to improve DMT cycle, screening throughput, assay design, and predictive relevance.
- Communicate progress and data clearly to internal stakeholders, cross-functional teams, and program leadership.
- Design and iterate multiparameter flow cytometry panels to evaluate CAR expression, T cell activation, memory/exhaustion phenotype, and cytotoxicity across construct formats and delivery modalities.
- Screen and rank CAR constructs delivered via mRNA (TNP/LNP). Build structure–activity relationships between CAR architecture and biological function in primary human and non-human primate T cells.
- Evaluate TNP/LNP formulations for delivery efficiency, correlating particle properties with transfection, expression kinetics, and cell viability.
- Run and continuously improve reporter-based functional assays for high-throughput CAR screening. Own assay sensitivity, dynamic range, and throughput.
Build the screening infrastructure
- Engineer and maintain target-expressing cell lines, reporter lines, and primary T cell assay platforms (co-culture, serial restimulation, multi-day killing kinetics) that bridge in vitro to in vivo.
- Establish B cell immunophenotyping panels for pharmacodynamic readouts in preclinical study samples.
Characterize the biology deeply
- Characterize in vitro–generated CAR-T cells deeply: subset distribution, exhaustion, metabolic fitness, and the relationship between transient CAR expression kinetics and effector function.
- Analyze samples from NHP and mouse studies to support translational biology. Interpret pharmacodynamic data and contribute to go/no-go decisions at project milestones.
Innovate and lead scientifically
- Generate, evaluate, and champion novel hypotheses. Read voraciously. Connect findings across disparate fields. Propose experiments that aren’t in the project plan.
- Integrate emerging technologies—lab automation, spectral flow, single-cell RNA-seq, high-content imaging—and AI tools (automated gating, dimensionality reduction, ML-guided experimental design) into workflows.
- Contribute to data visualization, presentations, patent filings, and publications. Comfort with Python, R, FlowJo, and Prism is expected. Facility with AI-assisted coding (Claude, Copilot) is valued.
Minimum Qualifications
- PhD or MS/Bachelors with 10+ years of industry experience in drug discovery or biotech environment.
- Strong working knowledge of T cell and B cell biology: activation, differentiation, exhaustion, memory formation.
- Experience in primary human immune cell isolation, culture, and functional assays (cytotoxicity, cytokine release, proliferation).
Additional Skills and Preferences
- Proven ability to drive SAR across the full DMT cycle.
- Fluency across biology and molecular design.
- Expert‑level multiparameter flow cytometry.
- Strong scientific judgment, rigor, and documentation.
- Experience with CAR‑T biology, mRNA therapeutics, and nanoparticle delivery.
- Cell line engineering and/or antibody engineering experience.
- Familiarity with spectral flow, high‑content imaging, and transcriptomics.
- Lab automation and data‑pipeline ownership experience.
- Advanced data analysis in Python or R; comfort using AI tools for analysis and design.
- Demonstrated scientific originality (publications, patents, or significant internal impact).
- Cross‑disciplinary collaborator with sharp biological intuition.
Why This Role
- A first‑in‑class in vivo CAR‑T platform with transformative clinical potential.
- Broad exposure across mRNA, nanoparticles, antibody engineering, and immunology.
- End‑to‑end ownership of molecule SAR in a team where data drives decisions.
- Direct influence on molecule selection, program direction, and go/no‑go calls.
- A high‑performing, scientifically rigorous team that values excellence, honesty, and intellectual courage.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
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Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$126,000 - $184,800
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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