Advisor, Immunoassay-based Biomarker Discovery and Analysis - Neuroscience

Eli Lilly Eli Lilly · Pharma · Boston, MA

This role focuses on the development and analysis of immunoassay-based biomarker methods for neurodegenerative diseases within a healthcare/pharmaceutical context. It involves laboratory work, method validation, and sample analysis for preclinical and clinical studies.

What you'd actually do

  1. Analyses as part of the development and validation of novel immunoassay-based biomarker methods, as well as apllications of these methods for clinical trials in neurodegenerative diseases, including Alzheimer’s, Parkinson’s, ALS, and rare brain disorders.
  2. Work with project team leads, including Dr. Kaj Blennow (Vice President of Neuroscience Biomarker Development), and other associates to perform experiments to support both the preclinical and clinical characterization and evaluation of therapeutic molecules through biomarker assay development.
  3. Assist with the planning and execution of immunoassay method developments, method optimization and validation, as well as sample analyses from different preclinical samples sets and clinical cohorts.
  4. Work directly on-site with methods in the laboratory, and with summarizing and reporting method status of results for internal partners.
  5. Implement assay validation procedures to deliver high performance biomarker assays for preclinical and clinical sample analyses.

Skills

Required

  • Bachelor’s degree in relevant area
  • 5+ years of industry, academic experience in protein biomarker analysis
  • Qualitative immunoassay-based analyses (e.g. electrophoresis techniques, Westen blot)
  • Quantitative immunoassay-based analyses (e.g. ELISA, MSD, Ella, Simoa, NULISA, SpearBio)
  • Principles of immunoassays (e.g. antibodies and other ligand-based molecules, assay design)
  • Protein biomarker quantification
  • Assay validation
  • Hands-on experience in protein biomarker applications (e.g. clinical diagnostics, clinical trials, or preclinical sample analysis)

What the JD emphasized

  • Must be technically skilled to in the field of qualitative (e.g. electrophoresis techniques, Westen blot) and quantitative (e.g. ELISA, MSD, Ella, Simoa, NULISA, SpearBio) immunoassay-based analyses.
  • Must have an understanding of the principles for immunoassays (e.g. antibodies and other ligand-based molecules, assay design), protein biomarker quantification, assay validation, as well as documented hands-on experience in protein biomarker applications (e.g. clinical diagnostics, clinical trials, or preclinical sample analysis).