Director, R&d Neuroscience Data, Data Science & Artificial Intelligence - Ophthalmology

Johnson & Johnson Johnson & Johnson · Pharma · San Diego, CA +7

Director role focused on leveraging AI/ML, computer vision, and generative AI with multimodal data (ophthalmic imaging, clinical, RWE) to accelerate drug discovery and development in ophthalmology, enhance clinical trial execution, and develop digital biomarkers and endpoints. The role involves advanced statistical modeling, RWE integration, and collaboration with cross-functional teams and external partners. The primary output is a patient-centric AI-driven product/solution for ophthalmic diseases.

What you'd actually do

  1. Drive the development and application of advanced AI/ML methods, including cutting-edge computer vision techniques applied to ophthalmic imaging data (e.g., Optical Coherence Tomography and fundus images), to uncover disease mechanisms and identify novel biomarkers.
  2. Lead the development and validation of novel digital endpoints. Engage with regulatory stakeholders to ensure these innovations enhance clinical trial design, improve patient monitoring and care pathways, and meet regulatory requirements.
  3. Develop and apply sophisticated statistical models using real-world and clinical data to generate insights into disease progression, treatment outcomes, and patient stratification. Leverage longitudinal disease modeling, Bayesian methodologies, and causal inference techniques to inform decision-making.
  4. Apply emerging generative AI approaches to boost data analysis and knowledge discovery, integrating diverse multimodal datasets (imaging, clinical, wearable, etc.) for a more holistic understanding of ophthalmic diseases.
  5. Partner with Clinical Development and Medical Affairs to integrate RWE into evidence generation strategies. Support trial optimization and regulatory submissions by incorporating insights from large-scale clinical datasets, electronic health records (EHRs), and other real-world data sources.

Skills

Required

  • PhD, MD, or equivalent in computational ophthalmology, neuroscience or a quantitative field such as biomedical engineering, data science, biostatistics, computational biology, or related discipline.
  • 8+ years of relevant industry or academic experience with a strong record of success in applying data science within biology/medicine, ideally influencing cross-disciplinary teams at the intersection of data science, biomedical research, and clinical development.
  • Experience in clinical development
  • Deep experience in computer vision and deep learning applied to biomedical imaging (especially ophthalmic imaging such as fundus photography and OCT).
  • Familiarity with model validation, reproducibility

Nice to have

  • experience in ophthalmology preferred

What the JD emphasized

  • advanced AI/ML methods
  • computer vision techniques applied to ophthalmic imaging data
  • novel digital endpoints
  • regulatory requirements
  • generative AI approaches
  • multimodal datasets
  • Real-World Evidence Integration
  • clinical development is required

Other signals

  • AI/ML methods
  • computer vision
  • ophthalmic imaging data
  • digital health technologies
  • generative AI
  • multimodal datasets
  • clinical trial execution
  • patient stratification
  • novel digital biomarkers and endpoints