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**Job Function: **
Discovery & Pre-Clinical/Clinical Development
**Job Sub Function: **
Biological Research
Job Category:
Scientific/Technology
All Job Posting Locations:
Beerse, Antwerp, Belgium
Job Description:
Johnson & Johnson Innovative Medicines is recruiting for an Experienced Scientist-Neurodegeneration, Neuroinflammation, and Translational Biology to contribute to a 3-year VLAIO-funded research program focused on neurodegenerative disease mechanisms and neuroinflammation in Alzheimer’s disease. This position will be located in located in Beerse, Belgium. This is a temporary, full-time position with a duration of 3 years.
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Our Neuroscience team tackles the world’s toughest brain health challenges including multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, myasthenia gravis, epilepsy, major depressive disorder, bipolar disorder, schizophrenia, and autism. This patient-focused team helps address some of the most complex diseases of our time.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at https://www.jnj.com/innovative-medicine
The successful candidate will play a leading experimental role in the development and application of advanced humanized in vitro and in vivo models to study Alzheimer’s disease in support of the VLAIO project. The candidate will be spending 90% of the time on lab work with a strong emphasis on complex iPSC-derived multi-cellular systems and humanized in vivo models. This role requires deep technical expertise and hands-on work, scientific independence, and the ability to translate biological questions into robust experimental strategies.
Key responsibilities:
Independently design, execute and interpret complex in vitro experiments using human iPSC-derived neurons, astrocytes, and microglia, as well as in vivo experiments, with minimal supervision or assistance. Drive experimental troubleshooting and continuous optimization of the model systems.
Apply a range of molecular, cellular, and biochemical techniques, such as immunohistochemistry, biochemical readouts (e.g., ELISA, protein analysis) and sample preparation for downstream omics analyses (e.g., bulk and single cell transcriptomics, proteomics).
Ensuring high-quality experimental execution and data generation, including accurate documentation and data recording in compliance with ELN standards, and timely reporting and communication of experimental results to supervisor, project teams and senior colleagues.
Perform general literature and research searches in support of data analysis and interpretation.
Collaborates effectively with cross-department team members and external collaborators to timely deliver on goals and objectives.
Understand and apply Johnson & Johnson’s Credo and Leadership Imperatives in day-to-day interactions with the team.
Education, Qualifications & Experience:
Master’s degree combined with demonstrated relevant experience and +6 years of work experience in pharma, or a PhD in Neuroscience may be considered.
Extensive hands-on experience with human iPSC-derived systems, including neurons, astrocytes, and microglia, is a must.
In vivo experience with rodent models is a plus. FELASA B certification is a minimal requirement, FELASA C certification is preferred.
Proven track record in neurodegeneration and neuroinflammation.
Experience in a range of molecular, cellular, and biochemical techniques for in vitro and ex vivo sample processing, such as immunohistochemistry, biochemical readouts (e.g., ELISA, protein analysis, MSD, Luminex, etc) and sample preparation for downstream omics analyses (e.g., bulk and single cell transcriptomics, proteomics)
Experience with single-cell sequencing approaches (e.g., scRNA-seq, single-nuclei RNA-seq) and downstream data interpretation is preferred.
Experience with live cell imaging (e.g. IncuCyte) and high content imaging is desired.
Expert in assay development, optimization and trouble shooting.
Experience integrating human in vitro and in vivo models in a translational research setting.
Additional skills:
- Strong analytical mindset with focus on data quality, reproducibility, and scientific rigor
- Ability to troubleshoot complex biological systems and adapt strategies
- Excellent communication and collaboration skills
- Proactive, innovative, and highly motivated
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please contact us via https://www.jnj.com/contact-us/careers or contact AskGS to be directed to your accommodation resource.
**Required Skills: **
Preferred Skills:
The anticipated base pay range for this position is:
€60,000.00 - €96,255.00
Benefits:
In addition to base pay, we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location, where the actual amount is based on the employees’ and companies’ performance of the previous calendar year, or sales commissions. Moreover, we offer vacation days, parental leave for a minimum of 12 weeks, bereavement leave, caregiver leave, volunteer leave, well-being reimbursement, programs for financial, physical and mental health. We also offer service anniversary and recognition awards, and subject to the terms of their respective plans, employees - and in some location’s eligible dependents - can participate in several insurance plans. For more information, visit Employee benefits | Supporting well-being & career growth | Johnson & Johnson Careers.
*This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.