Principal Scientist, Drug Discovery

Merck Merck · Pharma · NJ

Principal Scientist, Drug Discovery role at Merck, focusing on identifying new molecular entities and technologies for animal health. The role involves leading research programs from ideation through early research and proof-of-concept to development, interfacing with internal and external stakeholders. Requires a DVM/VMD and PhD in experimental pharmacology with at least 8 years of industry experience in drug discovery or preclinical research, with expertise in specific therapeutic areas and knowledge of regulatory aspects.

What you'd actually do

  1. Identifying new molecular entities and technologies for use in animal health from our Company Laboratories or from external partners such as human pharma or biotech companies as well as academia.
  2. Advance novel targets and will lead these research programs from ideation through the early research and proof-of-concept phase up to the development stage.
  3. Interface with researchers and senior management throughout the organization as well as external partners and operate within a matrix structure to garner resources for the necessary research work (Medicinal and Process Chemistry, in vitro Pharmacology, Pharmacokinetics, Disease Models, Formulation Development, Safety & Toxicology).
  4. Operate within a matrix structure to garner resources for the necessary research work (Medicinal and Process Chemistry, in vitro Pharmacology, Pharmacokinetics, Disease Models, Formulation Development, Safety & Toxicology).
  5. Report directly to the Distinguished Scientist and Global Head, our Company's Research & Development Liaison and Discovery – Non-infectious Diseases.

Skills

Required

  • Adaptability
  • Assay Development
  • Biochemical Assays
  • Cell Culture Techniques
  • Communication
  • Detail-Oriented
  • Ethical Compliance
  • Functional Genomics
  • In Vivo Models
  • Leading Project Teams
  • Molecular Biology Techniques
  • Persuasion
  • Professional Networking
  • Protein Biochemistry
  • Protein Purifications
  • Science
  • Social Collaboration
  • Virology

Nice to have

  • Board certification in Pharmacology
  • Project management skills within pharmaceuticals
  • Experience in developing and managing collaborations with outsource providers, vendors, contractors and academic institutions
  • Experience in working with business development to identify and license external technology opportunities

What the JD emphasized

  • Required: DVM/VMD, as well as a PhD in experimental pharmacology
  • Minimum of 8 years industry or pharmaceutical research experience in drug discovery or preclinical research with a focus on _in vivo_ pharmacology
  • Advanced and thorough scientific knowledge in pharmacology, disease mechanisms and related preclinical models
  • Expertise in one of the following fields: oncology, diabetes, respiratory & immunology, cardiology, pain & inflammation, reproduction, drug delivery or biotechnology
  • Knowledge of regulatory aspects of pharmaceuticals including GLP, GCP and GMP