At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com
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**Job Function: **
Discovery & Pre-Clinical/Clinical Development
**Job Sub Function: **
Biological Research
Job Category:
Scientific/Technology
All Job Posting Locations:
Cambridge, Massachusetts, United States of America
Job Description:
**About Innovative Medicine **
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at https://www.jnj.com/innovative-medicine
We are searching for the best talent for a Principal Scientist, Immunopeptidomics to be located in Cambridge, MA.
Purpose: Do you want to use your hard‑earned skills and drive to make a difference in the lives of patients? Join the growing Discovery Proteomic Platforms (DPP) group within the Discovery Technologies and Molecular Pharmacology (DTMP) department of Therapeutics Discovery to apply groundbreaking approaches to high‑scale proteomic analysis! Be part of a motivated team deploying** innovative mass spectrometry technologies** to tackle challenges in end‑to‑end drug discovery and development across a leading multiomics organization. We work shoulder‑to‑shoulder across biology, chemistry, and data science to deliver clear, reproducible proteomic readouts that move medicines forward. With your help, we will drive development of medicines for our patients!
Lead the development and delivery of immunogenicity assays supporting discovery programs across the Innovative Medicine portfolio. You will focus on hands‑on assay development, high‑throughput screening, and data generation, while working closely with diverse teams of protein engineers, data scientists, and biologists.
You will be responsible for:
- Leading must-win immunogenicity projects across biologics, CAR-T, and peptide therapeutics from early discovery through candidate selection.
- Owning the design, implementation, and execution of novel high throughput assays; continuously improving. methods and workflows to enhance efficiency and quality.
- Translating assay results into clear, decision-enabling interpretations for program and engineering teams. Ensuring strong data integrity, documentation, and reproducibility.
- Driving rapid innovation and providing technical leadership, while building strong multi-functional relationships as a scientific partner.
- Developing and operationalizing population-aware immunogenicity risk assessment strategies, ensuring consistent application across programs and integration within discovery and engineering cycles.
Qualifications / Requirements
Education:
- PhD in Immunology, Biochemistry, Cellular/Molecular Biology, Bioengineering or a related field is required.
Experience and Skills:
Required:
- 6+ years of proven biotech or pharmaceutical experience is required.
- Demonstrated expertise in immunology with hands-on experience developing, implementing, and interpreting complex immune cell-based assays is required.
- Strong cross-functional communication skills with the ability to translate multi-dimensional datasets into a decision-relevant narrative is required.
Preferred:
- Hands on experience with LC-MS instrumentation in support of immunopeptidomics workflows is preferred.
- Experience developing high-throughput assay workflows from pilot to scalable routine deployment is preferred.
- Hands-on experience with integrated lab automation systems is preferred.
- Familiarity with therapeutic engineering concepts is desirable.
- Experience working with in silico tools and integrating computational outputs with experimental data is preferred.
The anticipated base pay range for this position is $117,000 to $201,250.
The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis.
Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits:
- Vacation –120 hours per calendar year
- Sick time - 40 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
- Holiday pay, including Floating Holidays –13 days per calendar year
- Work, Personal and Family Time - up to 40 hours per calendar year
- Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
- Condolence Leave – 30 days for an immediate family member: 5 days for an extended family member
- Caregiver Leave – 10 days
- Volunteer Leave – 4 days
- Military Spouse Time-Off – 80 hours
Additional information can be found through the link below.
For additional general information on Company benefits, please go to:
- https://www.careers.jnj.com/employee-benefits
The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.
This job posting is anticipated to close on 06/02/2026. The Company may, however, extend this time-period, in which case the posting will remain available on https://www.careers.jnj.com to accept additional applications.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers, internal employees contact AskGS to be directed to your accommodation resource.
#LI-Onsite
Required Skills:
Preferred Skills:
Big Data Management, Critical Thinking, Data Reporting, Data Savvy, Drug Discovery Development, Molecular Diagnostics, Organizing, Pharmaceutical Microbiology, Problem Solving, Product Knowledge, Project Reporting, Project Schedule, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Standard Scientific Processes and Procedures, Strategic Thinking, Sustainability
The anticipated base pay range for this position is :
$117,000.00 - $201,250.00
Additional Description for Pay Transparency: