Senior Associate Scientist

Pfizer Pfizer · Pharma · Washington – Bothell, United States

This role supports the development of parenteral formulations for antibody-drug conjugates (ADCs) and monoclonal antibodies (mAbs) within Pfizer's biotherapeutics portfolio. Responsibilities include formulation development, analytical characterization using biophysical and biochemical techniques, supporting drug product manufacturing process development, and technical report writing. The role requires a Bachelor's or Master's degree in a relevant scientific discipline and hands-on laboratory experience with analytical techniques.

What you'd actually do

  1. Support development of parenteral formulations and manufacturing processes for ADCs and mAbs.
  2. Characterize candidate molecules and formulations to establish stability profiles using a broad range of biophysical and biochemical techniques (e.g., U/HPLC, imaged capillary electrophoresis (iCE), capillary gel electrophoresis (CGE), spectroscopy).
  3. Assist with scale-up of drug product processes (fluid handling, sterilizing filtration, lyophilization) from bench to pilot scale and support technology transfer to manufacturing facilities.
  4. Collaborate within team and cross‑functionally to advance formulation optimization and candidate progression.
  5. Summarize data, prepare presentations, and author technical reports to communicate results.

Skills

Required

  • Bachelor's degree in Biochemistry, Chemical or Biochemical Engineering, Pharmacy, Chemistry, Biology, or a related discipline with at least 2 years of relevant experience, or a Master’s degree in a relevant discipline with 0+ years of experience.
  • Hands-on laboratory experience with a variety of analytical techniques, which may include UPLC (SEC, IEX), capillary gel electrophoresis (CGE), imaged capillary electrophoresis (iCE), and spectroscopic methods.
  • Excellent problem‑solving and critical‑thinking skills used to solve scientific problems using experimental techniques, with contemporaneous recording of experimental details and data in an electronic laboratory notebook (ELN).
  • Ability to effectively communicate (oral and written) and collaborate, with experience working within multidisciplinary project teams
  • Strong attention to detail and a high level of accuracy in scientific work and documentation
  • Strong organizational and time‑management skills.
  • Proficiency with general computer software, including word processing, spreadsheets, and presentation tools.

Nice to have

  • Experience in formulation and process development for lyophilized ADC and/or mAb drug product
  • Hands-on experience with analytical techniques such as SE‑UPLC, RP‑UPLC, Karl Fischer titration, differential scanning calorimetry (DSC), freeze-drying microscopy (FDM), dynamic light scattering (DLS), etc.
  • Knowledge of current U.S. and global regulatory requirements, including FDA and ICH guidance.
  • Experience using common AI‑enabled tools, including generative technologies such as ChatGPT or Microsoft Copilot, to support problem solving and enhance productivity.

What the JD emphasized

  • Hands-on laboratory experience
  • analytical techniques
  • problem-solving
  • critical-thinking skills
  • multidisciplinary project teams
  • attention to detail
  • accuracy
  • organizational and time-management skills