Senior Computational Biologist, Special Projects

Amazon Amazon · Big Tech · Seattle, WA · Research Science

Senior Computational Biologist role focused on developing advanced computational methods and predictive models for complex, multi-modal datasets in the healthcare space. The role involves building interpretable models, integrating diverse data sources, and uncovering actionable insights, operating within an entrepreneurial and rapidly evolving environment.

What you'd actually do

  1. design end-to-end computational pipelines to process and analyze multi-modal data
  2. develop algorithms that integrate diverse information sources to generate predictions and actionable insights
  3. Building interpretable models that reveal underlying mechanisms and patterns will be central to your work
  4. collaborate with machine learning scientists and domain experts to ensure your approaches are both technically rigorous and practically impactful
  5. work with large-scale proprietary databases and scientific literature to identify meaningful signals

Skills

Required

  • 5+ years of applying statistical models for large-scale application and building automated analytical systems experience
  • Knowledge of Python or R or other scripting language
  • Experience in practical work applying ML to solve complex problems
  • PhD in a Computational Biology, Systems Biology or a related quantitative field
  • Experience analyzing complex, real-world datasets from diverse sources
  • Strong background in domain-specific knowledge graphs and structured data resources
  • Demonstrated expertise in integrating heterogeneous data types

Nice to have

  • Experience working with longitudinal or time-series data at scale
  • Knowledge of domain-specific modeling and outcome prediction
  • Familiarity with industry data standards and interoperability frameworks (HL7, FHIR, OMOP)
  • Experience with causal inference methods
  • Publication record in applied computational science or related fields
  • Strong communication skills and ability to translate technical concepts for non-technical audiences
  • Understanding of data privacy requirements and regulatory compliance

What the JD emphasized

  • entrepreneur
  • builder
  • dreamer
  • innovating at scale
  • ambitious vision
  • undefined problems
  • comfortable with ambiguity
  • entrepreneurial environment
  • early-stage, rapidly evolving environment

Other signals

  • develop advanced computational methods to analyze complex, multi-modal datasets
  • build predictive models and uncover actionable insights
  • develop algorithms that integrate diverse information sources to generate predictions and actionable insights
  • Building interpretable models that reveal underlying mechanisms and patterns