Senior Principal Scientist (r3-r4)

Eli Lilly Eli Lilly · Pharma · Indianapolis, IN

Senior Principal Scientist to execute experiments on the cutting edge of pharmaceutical sciences, supporting research programs for identified targets. This role involves overseeing portfolio programs independently, demonstrating laboratory expertise with biologic assays for drug development (mAb, ADC, and CD3 platforms), performing assay development, functional mAb screening and profiling, and evaluating in vitro and ex vivo assays. Requires a Master's degree and experience with phenotypic screens, cellular assays, multi-color flow cytometry, NanoString nCounter, RASL sequencing, and developing/optimizing flow cytometry, ELISA, and Luminex based functional assays in specific model systems.

What you'd actually do

  1. Execute experiments on the cutting edge of pharmaceutical sciences.
  2. Support research programs for identified targets.
  3. Oversee aspects of portfolio programs independently by demonstrating laboratory expertise with biologic assays aimed at drug development (mAb, ADC, and CD3 platforms).
  4. Perform assay development for specialized assays related to portfolio programs.
  5. Perform functional mAb screening and profiling.
  6. Conduct evaluation of both in vitro and ex vivo assays.

Skills

Required

  • Biomedical Engineering
  • Bioengineering
  • Drug development
  • mAb, ADC, and CD3 platforms
  • Phenotypic screens
  • Human myeloid cells
  • Immuno-oncology targets
  • Cellular assays
  • Multi-color flow cytometry
  • NanoString nCounter
  • RASL sequencing
  • ELISA
  • 32-plex Luminex based functional assays
  • Cancer vaccines
  • Murine models
  • Cynomolgus models

Nice to have

  • Part-time telecommuting

What the JD emphasized

  • Master’s degree in Biomedical Engineering, Bioengineering, or a related field
  • 2 years of experience with drug development with mAb, ADC, and CD3 platforms
  • 1 year of experience with phenotypic screens using human myeloid cells to identify novel immuno-oncology targets
  • 1 year of experience designing and implementing cellular assays to generate subsets of myeloid cells
  • 1 year of experience using multi-color flow cytometry, NanoString nCounter, and RASL sequencing to characterize myeloid culture systems
  • 1 year of experience developing and optimizing flow cytometry, ELISA, and 32-plex Luminex based functional assays to validate the response of protein-based cancer vaccines in murine and cynomolgus models