Senior Principal Scientist (r4)

Eli Lilly Eli Lilly · Pharma · San Francisco, CA

Senior Principal Scientist role at Eli Lilly focused on planning and implementing experiments using in vitro assays and technologies to support drug discovery. Requires experience with biochemical assays, cell culture, assay development, liquid handling systems, automation, data analysis software, and protein interaction technologies. The role supports small molecule discovery and SAR for multiple projects within a multidisciplinary team.

What you'd actually do

  1. Plan and implement experiments using in vitro assays and technologies to support drug discovery.
  2. Plan and implement experiments using biomedical assays, including absorbance and fluorescence-based assays including HTRF, AlphaScreen/Lisa, and Polarization, as well as cell assays with engineered cell lines.
  3. Support pioneering small molecule discovery and support SAR for multiple projects through their data and analysis within a multidisciplinary team.
  4. Generate high-quality, reproducible data by leveraging liquid handling, laboratory automation, and advanced data analysis tools.

Skills

Required

  • Biochemistry
  • Biology
  • in vitro assays
  • biomedical assays
  • HTRF
  • AlphaScreen/Lisa
  • Polarization
  • cell assays
  • engineered cell lines
  • small molecule discovery
  • SAR
  • liquid handling
  • laboratory automation
  • data analysis
  • GraphPad Prism
  • Dotmatics
  • protein interaction technologies
  • HiBiT
  • AlphaLisa
  • BLI

What the JD emphasized

  • Master’s degree in Biochemistry, Biology, or a related field, and 3 years of experience with biochemical assays, mammalian cell culture, and assay development.
  • 3 years of experience with liquid handling systems and automation, including Biomek, Hamilton, ECHO, and Integra
  • 3 years of experience with data analysis software, including GraphPad Prism or Dotmatics
  • 3 years of experience with protein interaction technologies, including: HiBiT, AlphaLisa, and BLI