Senior Scientist, Viral Vectors

Johnson & Johnson Johnson & Johnson · Pharma · Cambridge, MA +1

Seeking a Senior Scientist with expertise in viral vectors and molecular biology to contribute to CAR-T cell therapy discovery efforts. Responsibilities include viral vector generation, testing, optimization, and analytical quantification, as well as assay development and collaboration with cross-functional teams.

What you'd actually do

  1. Utilize your extensive knowledge in vector generation & testing, virology, and molecular biology to contribute meaningfully to our cell therapy platform and pipeline development.
  2. Conduct viral vector screening, optimize vector packaging and production, and perform analytical quantification of viral vector particles using relevant assessments including protein and PCR-based assays, particle potency testing via flow cytometry, and vector copy number (VCN) analysis.
  3. Play a key role in the development of innovative vector analytical and characterization assays.
  4. Leverage your familiarity with automation platforms to scale viral vector production, analytical testing, and cell-based activity measurements.
  5. Contribute to optimization efforts focused on increasing viral titers and purity to enhance the overall efficiency of production processes.

Skills

Required

  • Ph.D. in a relevant field (e.g. Pharmaceutical Science, Molecular Biology, Biochemistry, Biotechnology, etc.) with 1-2 years of relevant experience OR a Master’s or Bachelor’s degree with extensive experience.
  • Significant experience in enveloped viruses and viral vector production, analytical testing, and characterization.
  • Experience with lentiviral vectors required.
  • Demonstrated rigor in assay development and data analysis.
  • Strong knowledge of molecular/cell biology techniques, cell culture, and flow cytometry.
  • Highly organized and meticulous, with the ability to handle and pursue multiple projects in parallel with a high degree of autonomy.
  • Exceptional analytical and problem-solving skills to develop creative, innovative solutions and meet project objectives.
  • Strong collaboration skills and ability to operate effectively within a team environment.
  • Experience in maintaining accurate and detailed records of experimental procedures, data, and results in a well-organized electronic lab notebook to ensure reproducibility and accessibility for team members.
  • Excellent presentation, verbal communication, and scientific/technical writing skills.

Nice to have

  • Experience with high throughput assays, techniques, and workflows preferred.