Sr. Principal Scientist, Amazon Health Science & Analytics

Amazon Amazon · Big Tech · Santa Clara, CA · Applied Science

Senior AI/ML researcher to define ML strategy for a healthcare foundation model and inference system, focusing on frontier models, proprietary domain models, and monetizable features under regulatory constraints. Requires expertise in training/adapting large models, distributed training, RLHF/DPO, retrieval, evaluation, and ML systems engineering, with experience in high-stakes/regulated domains.

What you'd actually do

  1. Architect and guide a long-horizon ML strategy for a healthcare-focused organization building a durable, domain-specific healthcare foundation model and a high-reliability inference system.
  2. Define the technical vision for how our organization should leverage frontier models, when and how to build proprietary domain models, and how to sequence capability development into monetizable, customer-facing features while working high quality, safety, and regulatory constraints expected within healthcare.
  3. Serve as a senior technical advisor on frontier-model integration, data strategy, evaluation and safety architecture.
  4. Partner closely across product, engineering, clinical, and compliance teams to ensure that the AI system is safe, reliable, economically viable, and capable of compounding differentiation over time.
  5. Bring deep hands-on experience training or adapting large-scale models (LLMs, multimodal, or MoE systems), with strong grounding in distributed training, RLHF/DPO, retrieval and knowledge integration, evaluation harness design, and ML systems engineering.

Skills

Required

  • MS/PhD in computer vision, machine learning, computer science, or related quantitative and computationally intensive disciplines
  • 10+ years working in related AI domains
  • 5+ years of advising engineering and science teams
  • training or adapting large-scale models (LLMs, multimodal, or MoE systems)
  • distributed training
  • RLHF/DPO
  • retrieval and knowledge integration
  • evaluation harness design
  • ML systems engineering
  • experience shipping ML capabilities in high-stakes or regulated domains

Nice to have

  • familiarity with clinical data, workflow constraints, or ISO-aligned or internationally acknowledged safety practices and standards
  • healthcare, pharmaceuticals, biotechnology etc.

What the JD emphasized

  • high-reliability inference system
  • high quality, safety, and regulatory constraints
  • high-stakes or regulated domains
  • clinical data, workflow constraints, or ISO-aligned or internationally acknowledged safety practices and standards
  • Proven track record in shipping large scale AI/ML products
  • 5+ Language/multimodal model tuning and optimization experience

Other signals

  • architect and guide a long-horizon ML strategy
  • define the technical vision for how our organization should leverage frontier models
  • build proprietary domain models
  • sequence capability development into monetizable, customer-facing features
  • senior technical advisor on frontier-model integration, data strategy, evaluation and safety architecture
  • partner closely across product, engineering, clinical, and compliance teams
  • ideal candidate brings deep hands-on experience training or adapting large-scale models
  • strong grounding in distributed training, RLHF/DPO, retrieval and knowledge integration, evaluation harness design, and ML systems engineering
  • Demonstrated experience shipping ML capabilities in high-stakes or regulated domains
  • familiarity with clinical data, workflow constraints, or ISO-aligned or internationally acknowledged safety practices and standards
  • combine research depth, pragmatic product sense, and systems leadership
  • MS/PhD in computer vision, machine learning, computer science, or related quantitative and computationally intensive disciplines
  • Proven track record in shipping large scale AI/ML products
  • 10+ years working in related AI domains
  • 5+ Language/multimodal model tuning and optimization experience
  • 5+ years of advising engineering and science teams