Eli Lilly

Seeking a scientist-engineer hybrid to deploy AI-driven discovery platforms using foundation models, multi-agent systems, and robotics in drug discovery workflows. The role involves translating scientific workflows into agentic systems, integrating LLM reasoning with domain tools, and supporting model deployment and inference services.

This role focuses on building AI-orchestrated pipelines for biotherapeutics discovery, connecting generative design, property prediction, experiment selection, and result interpretation into a semi-autonomous loop with human oversight. It involves designing active learning pipelines for multi-objective optimization and using reinforcement learning to align generative models for desired therapeutic properties.

Associate Vice President leading the analytical methods and computational science pillar within Data Foundry, focusing on accelerating molecule discovery. This role involves leading a team of experts in cheminformatics, computational structural biology, statistical modeling, and AI/ML, ensuring Lilly has access to advanced analytical approaches for both human scientists and AI agents. The position requires strategic decision-making on adopting or developing methods, identifying data gaps, and establishing validation frameworks, with a strong emphasis on integrating methods into AI agent workflows.

This role focuses on applying statistical and computational approaches, including machine learning, to analyze large-scale multi-omics (genomic, proteomic, metabolomic) and clinical data from biobanks and population cohorts. The goal is to identify novel therapeutic targets and biomarkers for cardiometabolic diseases. The role involves developing and implementing bioinformatics pipelines, contributing to novel statistical methods, and collaborating with interdisciplinary teams to guide therapeutic development. While the primary focus is on data analysis and method development (L0/L2), the ultimate aim is to inform drug discovery and development.

This role focuses on applying AI/ML and automation within Chemical, Manufacturing, and Controls (CMC) disciplines in pharmaceutical R&D. The scientist will derive insights from data, build decision support tools, leverage LLMs to enhance data science workflows, and contribute to developing autonomous laboratories through AI-driven methodologies and lab automation. The primary focus is on data preparation, feature engineering, and potentially building agentic systems for experimental design and execution.

Postdoctoral Scientist role focused on developing synthesis-aware virtual screening workflows for early small-molecule drug discovery, integrating AI/ML with structure-based drug design and fragment chemistry.

Computational Biologist role focused on analyzing multimodal biological datasets (spatial and single-cell omics, proteomics, metabolomics, functional genomics) to advance target discovery in cardiometabolic diseases. The role involves developing predictive models, integrating diverse data types, applying AI/ML and causal inference methods, and influencing data architecture and analytical standards. Collaboration with internal AI and data engineering teams is key.

This role focuses on building and maintaining production genomics infrastructure for RNA drug discovery, including data pipelines from raw sequencer output to DataLake ingestion. It also involves contributing to ML models that predict pharmacology outcomes based on sequence design and collaborating with enterprise AI teams to integrate AI/ML capabilities into RNA-specific tools. The role requires expertise in bioinformatics, high-throughput NGS data analysis, and programming, with exposure to AI/ML methods in biological sequence data.

Director/Sr Director Pharmacometrics role at Eli Lilly focused on advancing drug discovery and development through quantitative science, with a strong emphasis on integrating AI/ML and automation into modeling workflows. The role involves scientific and technical leadership, mentoring, and shaping PMx strategy across programs and the organization, including engagement with regulatory agencies.

This role is for a Director of Molecular Pharmacology at Eli Lilly, focusing on designing and executing assays to support drug discovery programs. The role involves developing novel assay platforms, characterizing compound pharmacology, and providing scientific leadership. A key responsibility is to incorporate AI/ML into scientific workflows, though the core function is not AI/ML development itself.

Seeking an experienced drug hunter as a Discovery ADME Project Leader for Antibody Drug Conjugates (ADCs). The role requires deep mechanistic understanding of drug disposition, PK, and translational science, integrating biology, chemistry, and modeling. Responsibilities include developing integrated preclinical ADME strategies, driving ADME strategy by aligning pharmacokinetics, metabolism, and safety data, and guiding compound design. The role involves serving as the ADME single-point-of-accountability on cross-functional program teams, collaborating with various discovery functions, and contributing to candidate selection decisions. The position also requires implementing best practices, mentoring junior scientists, and leveraging AI/agentic tools where possible. A PhD in a related field and 6+ years of industry experience in drug discovery are required.

This role focuses on the biological aspects of an in vivo CAR-T platform, involving molecule SAR, screening, and characterization. It integrates emerging technologies including AI tools for analysis and design, but the core function is biological research in drug discovery, not AI model development.

This role focuses on preclinical drug discovery, specifically ADME (Absorption, Distribution, Metabolism, Excretion) and PK/PD (Pharmacokinetics/Pharmacodynamics). The Senior Advisor will develop integrated preclinical ADME strategies, integrate ADME and pharmacology for translational simulations, guide compound design based on data-driven principles, and serve as the ADME single-point-of-accountability on cross-functional program teams. The role also involves mentoring junior scientists and implementing procedures, assay innovation, and automation, with a stated interest in leveraging AI and agentic tools where possible.

Scientist/Sr. Scientist role focused on protein engineering, specifically antibody optimization and phage display-based discovery within a healthcare/biotechnology research division. Involves molecular biology, biochemistry, and developing/optimizing assays.

The Associate Director - Medical Science Liaison (MSL) for Cardiometabolic Health at Eli Lilly is responsible for engaging with scientific and clinical experts to provide in-depth scientific and clinical information about specific disease states and Lilly's compounds. This role involves synthesizing the latest research, responding to medical information needs, facilitating scientific exchange, and communicating insights to internal teams. The MSL acts as a key interface between Lilly Medical and healthcare professionals, supporting clinical care gaps and potentially facilitating collaborative research. The role also involves territory management, strategic planning, and ensuring compliant partnerships.

This role focuses on scientific and clinical exchange within the cardiometabolic health therapeutic area, acting as a liaison between Eli Lilly and healthcare professionals (SEs/CEs). The Associate Director will provide in-depth scientific and clinical information, gather insights, and support research and development efforts. The role requires deep content knowledge, continuous learning, and strategic engagement with key opinion leaders.

Executive Medical Director role in Early Clinical Development for the Immunology team at Eli Lilly, focusing on developing transformational medicines for autoimmune and inflammatory diseases. The role involves strategic leadership, designing and executing early clinical studies, integrating translational endpoints, and collaborating with cross-functional teams, regulatory affairs, and external experts. Requires a physician scientist with strong clinical translational experience and leadership skills.

This role focuses on NMR spectroscopy and reaction characterization within the pharmaceutical industry, specifically for small molecule therapeutics, synthetic peptides, and oligonucleotides. The primary responsibilities include designing and interpreting NMR experiments, solving complex structure elucidation challenges, and applying quantitative NMR methods. While the role mentions familiarity with AI-enabled workflows as a preference, its core function is not AI/ML development.

Associate Director for Clinical Research in Oncology, responsible for driving clinical trial execution through investigator engagement and site performance management. This role requires deep therapeutic and scientific knowledge to influence investigators, ensure protocol understanding, and develop enrollment strategies. The CRL acts as a trusted partner to investigators, collaborating with internal teams to shape development strategies and ensure operational excellence. Responsibilities include investigator management, clinical trial management, business management, and country/regulatory engagement.

Associate Director - Medical Science Liaison for Cardiometabolic Health at Eli Lilly. This role focuses on providing in-depth scientific and clinical information to healthcare professionals and researchers within a specific therapeutic area. The MSL acts as a key interface, facilitating scientific exchange, sharing insights, and supporting clinical development and research opportunities. Requires advanced scientific/clinical acumen and experience in a relevant health science field.

The Director, RWE, CMH role at Eli Lilly is responsible for developing and executing the Real-World Evidence strategy within Medical Affairs. This involves designing and overseeing observational studies, registries, and other real-world data analyses to inform clinical practice, regulatory decisions, and healthcare policy. The role requires collaboration with various internal and external stakeholders, including HEOR, Market Access, Regulatory, and KOLs, to generate and disseminate high-quality evidence across the product lifecycle.

This role is for a Synthetic Chemist/Peptide Therapeutics Advisor in Biotechnology Discovery Research. The individual will design, synthesize, optimize, and characterize therapeutic peptides and bioconjugates, leading hands-on research, driving SAR strategies, and generating data for project decisions. The role involves integrating knowledge across peptide chemistry, bioconjugation, and pharmaceutical developability, collaborating cross-functionally, and contributing to scientific productivity through publications and patents.

This role is for a Lead Chemist in RNAi drug discovery at Eli Lilly. The primary focus is on evaluating scientific opportunities, designing and executing RNAi therapeutic projects, and managing partnerships. While the role mentions AI/ML tools as part of a broader ecosystem, the core responsibilities are in traditional drug discovery and chemistry, not in building or researching AI/ML models.

Scientist role focused on developing and optimizing analytical methods for small molecule drug substances and synthetic intermediates, leveraging techniques like HPLC, GC, NMR, and MS to support drug candidate development from early stages through manufacturing readiness. This role involves close collaboration with synthetic chemists and process engineers in a laboratory setting.

Student role in Medical Affairs Neuroscience focusing on researching scientific trends in dementia, analyzing preclinical and clinical study data, conducting literature reviews, and supporting the creation of medical materials and scientific events.

Seeking an experienced discovery biologist to provide scientific leadership and hands-on expertise to shape early research strategy and advance novel therapeutic concepts for osteoporosis at Eli Lilly. This role involves driving mechanism-based discovery, maintaining a laboratory presence, designing and conducting experiments, and contributing to cross-functional project teams.

This role focuses on applying mass spectrometry techniques to characterize the pharmacokinetic, biotransformation, and biodistribution properties of therapeutic proteins and genetic medicine modalities in preclinical animal models within the Bioanalytical Research Group at Eli Lilly. It involves developing and implementing LC/MS approaches and collaborating with project teams. The role requires a Master's or Bachelor's degree in a relevant scientific field with significant work experience in protein and oligonucleotide mass spectrometry and bioanalysis.

This role focuses on discovery research in preclinical women's health, specifically preeclampsia, involving target identification, hypothesis development, and advancing preclinical biology. It requires a PhD in a related field and hands-on laboratory experience with in vitro, ex vivo, and in vivo models.

Seeking a scientist to develop and apply advanced in vitro models (co-culture systems, iPS-derived cells, spheroids, organoids, organ-on-a-chip) or new approach methodologies (NAMs) to address mechanistic/investigative toxicology questions in drug discovery. The role involves qualifying novel assays, investigating mechanisms of compound-induced toxicity, and collaborating with external partners.

This role focuses on developing analytical methods and supporting gene therapy pipeline progression at Eli Lilly. It involves assay development, characterization of viral proteins, AAV vector design, and analytical support for vector core groups. The position also requires expanding analytical capabilities and coaching junior scientists.

Post-doctoral Biologist role at Eli Lilly focused on discovering and advancing peptide and antibody drugs. Responsibilities include developing rodent models, executing in vivo studies, performing cell culture and assays, analyzing data, and collaborating with internal and external teams. Requires a Ph.D. in Biology, proficiency in in vivo studies, and experience with small animal surgery and cell-based assays.

Director of Regenerative Biology at Eli Lilly, leading preclinical inner ear regeneration programs. Focuses on scientific strategy, study design, execution, and external collaborations for gene therapy and regenerative approaches. Requires PhD and extensive experience in inner ear biology or related fields, with a track record of advancing programs through preclinical development.

Senior/Executive Director Clinical Research Physician focused on Breast Cancer and PI3K pathway drugs within Eli Lilly's Global Medical Affairs organization. This role involves strategic planning, drug development support, commercialization activities, engaging with external stakeholders (KOLs, investigators), and leading a team of medical affairs professionals. The primary focus is on improving patient outcomes through scientific and medical expertise, particularly for tersolisib, a PI3Ki in late-phase development.

This role focuses on the design and development of drug products for synthetic molecules within the pharmaceutical industry. It involves applying fundamental pharmaceutical sciences, predicting in vivo performance using molecular properties and preclinical data, and leveraging modeling to guide formulation development. The position also requires collaboration with partners, influencing scientific communities, and authoring technical reports and regulatory documentation. While it involves modeling and data analytics, the core function is not AI/ML model development but rather drug product research and development in a healthcare context.

Associate Scientist role in drug target identification and validation for CNS diseases, focusing on psychiatric disorders. Responsibilities include designing and executing rodent in vivo studies, stereotaxic surgeries, tissue collection, and quantitative immunohistochemistry (IHC) and immunofluorescence (IF) workflows. The role also involves molecular and biochemical assays, collaboration with multidisciplinary teams, and presenting experimental results. Requires an MS in Neuroscience, Biology, or Pharmacology with 2-5 years of lab experience in in vivo rodent work and IHC.

This role focuses on developing and implementing Real-World Evidence (RWE) strategies within the healthcare domain, specifically at Eli Lilly. The Advisor will plan, conduct, and communicate results from Real-World and Health Outcomes studies, such as database studies and chart reviews. Responsibilities include managing RWE projects, collaborating with internal teams and external partners, and ensuring adherence to research principles and regulatory guidelines. The ideal candidate has a strong academic background (PhD or Master's) in a relevant field and prior experience in Real-World Research.

Clinical Research Physician specializing in Ophthalmology Gene Therapy Development at Eli Lilly. This role involves the development, conduct, and reporting of global clinical trials for ophthalmologic products, including protocol review, patient safety monitoring, adverse event reporting, and scientific data dissemination. The physician will serve as a medical resource for study teams and external healthcare professionals, collaborating on clinical strategy, trial execution, and regulatory support.

Executive Director role focused on early clinical development in neuroscience drug development, involving clinical pharmacology and mechanistic studies. Responsibilities include leading clinical trials, reporting adverse events, reviewing protocols, and ensuring compliance with regulations and GCPs. Requires an M.D. or D.O. with at least five years of relevant experience.

This role focuses on leading PKPD project strategy for genetic medicines programs, developing and implementing modeling strategies to enhance decision-making in drug discovery and development. It involves designing, analyzing, and interpreting quantitative pharmacology studies, collaborating with cross-functional teams, and mentoring junior scientists. The role requires expertise in PK/PD and PBPK modeling, experience with relevant software, and a PhD in a related field.

This role is for a Senior Director in Oncology and Peripheral Imaging Clinical Development at Eli Lilly. The primary focus is on leading the clinical development of imaging strategies for oncology, immunology, and cardiometabolic diseases, spanning early to late-phase trials. While the role involves evaluating AI in imaging, its core function is in clinical research and development within the healthcare domain, not in building or shipping AI models.

This role is for a Director/Senior Director/Executive Director in AAV R&D at Eli Lilly, focusing on inventing, characterizing, and advancing novel genetic reagents for clinical applications. The responsibilities include developing AAV therapies, driving data-based decisions, implementing strategic vision, leading screening of AAV technologies, ensuring best practices in model development and validation, and leading a team. The role requires a PhD with 10+ years of industry experience, with a mastery of ophthalmology gene therapy and proven experience in leading gene therapy programs.

This role focuses on leading and executing in vivo and PET imaging studies, including experimental design, advanced image analysis, and data interpretation within the healthcare domain. The scientist will integrate cutting-edge imaging technologies and novel agents into research pipelines, collaborate with global leaders, and disseminate findings through publications and presentations. The role requires a Bachelor's or Master's degree with at least 7 years of experience in molecular imaging and a strong publication record.

Director level role focused on clinical design for cardiometabolic health at Eli Lilly. Responsibilities include translating therapeutic area strategy into clinical development programs and trial optionality, developing study protocols, collaborating with cross-functional teams, and ensuring compliance with regulations. The role requires medical expertise and pharmaceutical industry experience in drug development and clinical trial design.

This role is for a Director in Discovery Immunology at Eli Lilly, focusing on developing biological strategy for new target validation, from target identification through mechanistic validation. The ideal candidate will have deep expertise in functional genomics, phenotypic and mechanistic discovery platforms, and primary human model systems. The role involves leading cross-functional discovery teams, driving scientific decision-making, and expanding functional genomics capabilities. This is a research-focused role within the healthcare domain, not directly related to AI/ML model development.

Research scientist role focused on developing and utilizing in vivo models to understand immunological mechanisms for drug discovery in autoimmune diseases. Responsibilities include leading research studies, hands-on laboratory work, data analysis, and mentoring junior scientists.

This role focuses on bioconjugation process development for new bioconjugate medicines, including ADCs, APCs, and AOCs. The scientist will establish laboratory programs, design and execute research plans, analyze results, and propose next steps. Responsibilities include learning and applying bioconjugation techniques, purification screening, experimental design, and analytical sample analysis. The role involves collaboration across disciplines, performing fundamental studies of process steps, scale-up demonstrations, and proposing new methods. Documentation, report authoring, and contributing to commercial manufacturing strategy are also key. The role requires a BS or MS in a relevant scientific field with several years of experience in synthetic organic chemistry or biochemistry.

This role focuses on developing and executing health outcomes and real-world evidence (HEOR/RWE) strategies for pharmaceutical products in Japan. It involves scientific leadership in evidence generation, study design, analysis, and dissemination to support drug development, market access, and product value demonstration. The role requires collaboration with cross-functional teams and external stakeholders, and an understanding of healthcare systems and relevant regulations.

Senior Advisor, Clinical Research role at Eli Lilly in Shanghai, focusing on the design, execution, and interpretation of clinical trials for new medicines. Requires an MD degree, clinical research experience, and strong understanding of drug development processes and regulatory requirements.